Organization away from urinary salt and you can potassium removal that have systolic blood pressure levels about Diet Methods to Avoid Blood pressure level Sodium Demonstration

Organization away from urinary salt and you can potassium removal that have systolic blood pressure levels about Diet Methods to Avoid Blood pressure level Sodium Demonstration

The 2019 National Academy of Science, Engineering and Medicine Dietary Reference Intakes (DRI) for Sodium (Na + ) and Potassium (K + ) Report concluded there remains insufficient evidence to establish a K + DRI. This study tested the hypothesis that reduced Na + and increased K + excretion will positively associate with lower blood pressure in salt sensitive (SS) and salt resistant (SR) participants in the Dietary Approaches to Stop Hypertension Sodium Trial (DASH–Sodium). Via the NHLBI BioLINCC we accessed the DASH-Sodium dataset for data on systolic blood pressure (SBP), 24-h urinary Na + and K + excretion at screening (regular patient diet; N = 186, SS N = 222 SR) and post DASH diet (N = 71 SS, N = 119 SR). The relationships between SBP, urinary Na + and K + excretion, and Na + /K + ratio were assessed via linear regression. At screening elevated urinary Na + excretion positively associated with SBP in SS (1 g increase in urinary Na https://datingranking.net/pl/date-me-recenzja/ + excretion = +1 0 ± 0.4 mmHg) but not SR participants, and urinary K + excretion of <1 g K + /day was associated with higher SBP in SS and SR participants. Urinary K + excretion ?1 g/day, or a decreases in urinary Na + /K + ratio, was not associated with lower SBP. Post the DASH–sodium diet intervention, SBP was reduced in SS and SR participants. However, no correlation was observed between reduced SBP and urinary K + excretion or the urinary Na + /K + ratio irrespective of the salt sensitivity of blood pressure. Our data support the DRI recommendation not to establish a K + DRI and suggest further evidence is required to support a reduced Na + /K + ratio to lower SBP.

Inclusion

Hypertension, typically the most popular non-communicable disease international, stands for a significant globally personal ailment. According to research by the 2017 Western Cardio Organization (AHA) assistance, brand new incidence off blood circulation pressure in our midst adults was estimated to-be 46% ; on top of that,

Organization out of urinary sodium and you can potassium excretion with systolic blood pressure level on Fat reduction Remedies for Stop Blood pressure levels Sodium Demo

50% from hypertensive people are estimated become salt painful and sensitive (SS) . Given that noted from the Federal Cardiovascular system having Persistent Disease Cures and Health Campaign statement

90% from American people consume an excess of diet salt (Na + ), which have the common daily consumption exceeding 3400 mg within the mature All of us guys, an esteem nearly 3 times the brand new each and every day application demanded because of the AHA while the Federal Academy off Research, Engineering, and you may Drug Slimming down Reference Consumption (DRI) . Since an excessive amount of dieting Na + consumption, which can drive the fresh salt awareness out-of blood circulation pressure and increase blood pressure level exposure, global weight-loss Na + intake was a community health risk. The brand new feeling away from weightloss Na + intake into the blood pressure levels has been examined when you look at the several fat loss input trials producing evidence that faster dieting sodium consumption in the managed options causes decreases from inside the blood pressure level [6,seven,8]. Further, meta-analyses provides coordinated fat loss Na + limitation that have decreases when you look at the hypertension indicating there was a health work for in normotensive and you will hypertensive some body regardless of the sodium sensitiveness off blood pressure [9, 10].

Recent evidence suggests the salt sensitivity of blood pressure may be modulated, in part, by dietary potassium (K + ) intake. Increasing dietary K + intake appears to counteract the effects of dietary Na + intake on increasing blood pressure [11,12,13]. Despite several studies that have documented blood pressure lowering effects of increasing K + intake, the 2019 National Academy of Science, Engineering, and Medicine DRI for sodium and potassium Report did not establish a DRI for K + . This report concluded that more evidence is required to support a DRI of K + with particular reference to a lack of K + dose-response trials limiting the evidence to establish a K + DRI . Several studies have reported that the urinary Na + :K + ratio has a stronger association with blood pressure than Na + or K + independently [14, 15]. Largely based on these data, a urinary Na + to K + molar ratio of <1 has been recommended [16, 17] as a beneficial target to improve long-term blood pressure control. Given the high global dietary Na + intake this would necessitate dietary, or other means, of K + supplementation-for which a DRI has not been established . A leading dietary intervention study was the Dietary Approaches to Stop Hypertension 2 Trial (DASH-Sodium) conducted between 1997 and 2002 . The DASH-Sodium trial was a multicenter, randomized clinical trial that examined the impact of three levels dietary Na + intake in combination with either a control or DASH diet (rich in fruits, vegetables, and low-fat dairy products, and reduced in total fat) on blood pressure. This study demonstrated substantial effects of dietary Na + reduction and the DASH diet on reducing blood pressure, with more significant blood pressure lowering effects with the combination of a DASH diet plus dietary Na + reduction than dietary Na + restriction alone in individuals with higher than optimal blood pressure . Given that the DASH diet intervention elevated dietary K + intake by increasing dietary intake of fruits and vegetables in combination with modifying daily dietary Na + intake, examining the potential interaction between dietary Na + and K + intake on blood pressure in the DASH trial will provide valuable insight into the potential influence of dietary K + on blood pressure.

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